Rocsur Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Side Effects Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Rocuronium Br

Indications/Uses

Adjunct to general anesth to facilitate endotracheal intubation & mechanical ventilation, provide skeletal muscle relaxation in adults, childn & infants from 1 mth. Adjunct in ICU to facilitate mechanical ventilation & as part of rapid sequence induction in adults.

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Dosage/Direction for Use

Tracheal intubation & rapid sequence anesth induction during caesarian section Standard dose: 0.6 mg/kg. Rapid sequence anesth induction 1 mg/kg. Maintenance: 0.15 mg/kg. Long-term inhalation anesth 0.075-0.1 mg/kg. Continuous infusion Loading dose: 0.6 mg/kg. IV anesth Infusion rate: 0.3-0.6 mg/kg/hr. Inhalation anesth 0.3-0.4 mg/kg/hr. Infant 28 days-23 mth, childn 2-11 yr & adolescent 12-18 yr Adult dose. Geriatric & patient w/ hepatic &/or biliary tract disease &/or renal failure 0.6 mg/kg. Maintenance: 0.075-0.1 mg/kg. Infusion rate: 0.3-0.4 mg/kg/hr. Intensive care procedures Maintenance: Initially 0.6 mg/kg loading dose followed by continuous infusion as soon as twitch height recovers to 10% or upon re-appearance of 1-2 twitches to train of 4 stimulations. Adult 0.3-0.6 mg/kg/hr during 1st hr, may be decreased during the following 6-12 hr.

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Overdosage

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Contraindications

Hypersensitivity to rocuronium or Br ion.

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Special Precautions

Anaphylactic reactions; allergic cross-reactivity. Conditions associated w/ prolonged circulation time eg, CV disease, oedematous state; neuromuscular disease or after poliomyelitis; myasthenia gravis or myasthenic (Eaton-Lambert) syndrome; hypothermia; obesity; burns; hypokalaemia, hypermagnesemia, hypocalcemia, hypoproteinemia, dehydration, acidosis, hypercapnia, cachexia. Correct severe electrolyte disturbances, altered blood pH or dehydration. Long-term use. Clinically significant hepatic &/or biliary disease &/or renal failure. Pregnancy & lactation. Not recommended for facilitating tracheal intubation conditions during rapid sequence induction in ped patients. Neonates 0-1 mth. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Anaphylactic/anaphylactoid reactions, local inj site pain/reaction.

Drug Interactions

Increased effect w/ halogenated volatile anesth, suxamethonium, corticosteroids (long-term use); antibiotics (aminoglycosides, lincosamide, polypeptide, acylamino-penicillin), diuretics, quinidine, quinine, Mg salts, Ca-channel blockers, lithium salts, local anesth (lidocaine IV, epidural bupivacaine), phenytoin or β-blockers. Recurarization w/ aminoglycoside, lincosamide, polypeptide, acylamino-penicillin, quinidine, quinine, Mg salts. Decreased effect w/ phenytoin or carbamazepine; PIs (gabexate, linastatin). Attenuated/potentiated neuromuscular-blocking effect w/ other non-depolarizing neuromuscular blockers, suxamethonium. Quicker onset of lidocaine action.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Rocsur detailed prescribing information

Storage

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Description

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Action

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MIMS Class

Neuromuscular Blocking Agents

ATC Classification

M03AC09 - rocuronium bromide ; Belongs to the class of other quaternary ammonium-containing agents used as peripherally-acting muscle relaxants.

Regulatory Classification

Presentation/Packing

Form

Rocsur soln for inj 10 mg/mL

Packing/Price

5 mL x 1's

Rocsur

rocuronium bromide

Manufacturer:

Gland Pharma

Distributor:

Unimed