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Live attenuated virus vaccines: Active immunisation with live virus vaccines (e.g. measles, mumps, rubella or varicella) should be postponed until 3 months after the last administration of anti-D immunoglobulin, as the efficacy of the live virus vaccine may be impaired. If anti-D immunoglobulin needs to be administered within 2 to 4 weeks of a live virus vaccination, then the efficacy of such a vaccination may be impaired.
Interference with serological testing: After injection of immunoglobulin the transitory rise of the various passively transferred antibodies in the patient's blood may result in misleading positive results in serological testing. Passive transmission of antibodies to erythrocyte antigens, eg, A, B, Rh(C), Rh(D) may interfere with some serological tests for RBCs antibodies e.g. the antiglobulin test (Coombs' test), particularly in Rh(D) positive neonates whose mothers have received antepartum prophylaxis.
