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RENITEC is contraindicated in patients who are hypersensitive to any component of this product and in patients with a history of angioneurotic edema relating to previous treatment with an angiotensin-converting enzyme inhibitor and in patients with hereditary or idiopathic angioedema.
RENITEC should not be administered with aliskiren in patients with diabetes (see INTERACTIONS).
RENITEC is contraindicated in combination with a neprilysin inhibitor (e.g., sacubitril). Do not administer RENITEC within 36 hours of switching to or from sacubitril/valsartan, a product containing a neprilysin inhibitor. (See PRECAUTIONS and INTERACTIONS.)
