Essential Mild HTN Initially 10 mg daily.
Other degrees of HTN Initially 20 mg daily. Maintenance: 20 mg once daily. Max: 40 mg daily.
Renovascular HTN Initiate w/ lower starting dose (eg, ≤5 mg) & adjust accordingly to patient's needs.
Mild renal impairment (CrCl >30 to <80 mL/min) Initially 5-10 mg daily.
Moderate renal impairment (CrCl >10 to ≤30 mL/min) Initially 2.5-5 mg daily.
Severe renal impairment (CrCl ≤10 mL/min) Initially 2.5 mg daily on dialysis days, adjusted depending on BP response on nondialysis days.
Heart failure/asymptomatic left ventricular dysfunction Initially 2.5 mg administered under close medical supervision to determine initial effect on BP, may be increased gradually to 20 mg in single or 2 divided doses as maintenance over 2-4 wk period.
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