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Parentally administered iron preparations can cause allergic or anaphylactoid reactions, which can be potentially fatal. Therefore, antiallergic treatment should be in place with the established cardio-pulmonary resuscitation procedures.
In patients with history of asthma, eczema, other atopic allergies or allergic reactions to other parenteral iron preparations, Ranofer should be administered with care as they are particularly at risk of an allergic reaction.
Ranofer should be administered with care in patients with liver dysfunction.
Ranofer must be used with care in patients with acute or chronic infection who have excessive ferritin values as parenterally administered iron can unfavourably influence bacterial or viral infection.
Paravenous leakage must be avoided because leakage of Ranofer at the injection site may lead to pain, inflammation, tissue necrosis and brown discoloration of the skin.
