Not to be inj by SC or intrathecally. Aniline-induced methaemoglobinaemia, dapsone-induced haemolytic anaemia; hyperglycaemia or DM; cytochrome b
5 reductase & G6PD deficiency or sulfhaemoglobinemia. May cause bispectral index interference in patients receiving dapsone therapy. False estimation of O
2 saturation w/ use of pulse oximetry. Monitor ECG & BP levels during & after treatment. Frequently check Hb conc & monitor methaemoglobin level during therapy. May impart blue-green colour to urine, stool & blue colour to skin. Avoid exposure to strong light sources eg, phototherapy, operating theatres or illuminating devices eg, pulse oximeters. Long-term use. Avoid concomitant use w/ SSRIs, SNRIs, MAOIs. May affect ability to drive & use machines. Hepatic & moderate or severe renal impairment; ESRD w/ or w/o dialysis. May affect male & female fertility. Not to be used during pregnancy & lactation. Not recommended in infants <4 mth.
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