ProQuad Description

Before reconstitution, ProQuad is a lyophilized plug that appears as white to faint yellow crystalline pellet. ProQuad, when reconstituted, is a pale yellow to light pink liquid.
Active Ingredients: ProQuad, when reconstituted as directed, is a sterile preparation for subcutaneous administration. Each 0.5-mL dose contains not less than 3.00 log₁₀ TCID₅₀ (50% tissue culture infectious dose) of measles virus; 4.30 log₁₀ TCID₅₀ of mumps virus; 3.00 log₁₀ TCID₅₀ of rubella virus; and a minimum of 3.99 log₁₀ PFU (plaque-forming units) of Oka/Merck varicella virus.
Excipients/Inactive Ingredients: Each 0.5-mL dose of the vaccine contains no more than 20 mg of sucrose, 11 mg of hydrolyzed gelatin, 2.5 mg of urea, 2.3 mg of sodium chloride, 16 mg of sorbitol, 0.38 mg of monosodium L-glutamate, 1.4 mg of sodium phosphate, 0.25 mg of recombinant human albumin, 0.13 mg of sodium bicarbonate, 94 mcg of potassium phosphate, 58 mcg of potassium chloride; residual components of MRC-5 cells including DNA and protein; 5 mcg of neomycin, bovine serum albumin (0.5 mcg), and other buffer and media ingredients. The product contains no preservative. This product contains trace quantities of ingredients of porcine source.
The cells, virus pools, bovine serum, and recombinant human albumin used in manufacturing are all screened to ensure the absence of adventitious agents.