ProQuad Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Side Effects Drug Interactions Storage MIMS Class ATC Classification Presentation/Packing

Concise Prescribing Info

Contents

Per 0.5 mL Measles virus Enders' Edmonston strain (live, attenuated) not <3 log₁₀ TCID₅₀, mumps virus Jeryl Lynn (B level) strain not <4.3 log₁₀ TCID₅₀, rubella virus Wistar RA 27/3 strain (live, attenuated) not <3 log₁₀ TCID₅₀, varicella virus Oka/Merck strain not <3.99 log₁₀ PFU

Indications/Uses

Vaccination against MMR & varicella in individuals 12 mth-12 yr.

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Dosage/Direction for Use

0.5 mL single SC dose.

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Overdosage

View ProQuad overdosage for action to be taken in the event of an overdose.

Contraindications

Hypersensitivity to vaccine including gelatin; neomycin. Blood dyscrasias, leukemia, lymphomas or other malignant neoplasms affecting bone marrow or lymphatic system. Immunosuppressive therapy eg, high-dose corticosteroids. Primary & acquired immunodeficiency states. Family history of congenital or hereditary immunodeficiency. Active untreated TB; active febrile illness w/ fever >38.5°C. Avoid pregnancy for 3 mth following vaccination.

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Special Precautions

Not to be inj intravascularly. Not to be given w/ Ig or varicella-zoster Ig. History of anaphylactic, anaphylactoid or other immediate reactions subsequent to egg ingestion. Family history of convulsions, history of cerebral injury or other condition in which stress due to fever should be avoided. HIV-infected w/ or w/o immunosuppression; thrombocytopenia; post-exposure prophylaxis. Avoid close association w/ high-risk individuals eg, immunocompromised, pregnant women & newborn infants w/o documented +ve history of varicella or lab evidence of prior infection for up to 6 wk following vaccination. Monitor temp elevation following vaccination. Temporary depression of tuberculin skin sensitivity. Avoid pregnancy for 3 mth following vaccination in women of childbearing potential. Not to be used during pregnancy. Lactation. Not recommended in infants <12 mth.

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Use In Pregnancy & Lactation

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Adverse Reactions

Fever ≥38.9°C, inj site erythema, pain/tenderness/soreness. Upper resp infection; irritability; diarrhea, vomiting; measles- & varicella-like rash, rash; inj site ecchymosis or swelling, rash.

Drug Interactions

Interfered immune response w/ Ig. Reye syndrome w/ salicylates; avoid use 6 wk after vaccination. Defer vaccination at least 3 mth following blood or plasma transfusions or Ig administration. Not to administer varicella-zoster Ig for 1 mth after administration. At least 1 mth should elapse between MMR vaccine & ProQuad; at least 3 mth should elapse between 2nd dose varicella-containing vaccine.

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Storage

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Description

View ProQuad description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Vaccines, Antisera & Immunologicals

ATC Classification

J07BD54 - measles, combinations with mumps, rubella and varicella, live attenuated ; Belongs to the class of measles vaccines.

Presentation/Packing

Form

ProQuad vaccine (inj) (lyo, vial) 0.5 mL

Packing/Price

1's

ProQuad

Manufacturer:

Merck Sharp & Dohme

Distributor:

Zuellig Pharma