Precedex Dosage/Direction for Use

Dosing Guidelines: Precedex dosing should be individualized and titrated to desired clinical response.
Precedex is not indicated for infusions lasting longer than 24 hours.
Precedex should be administered using a controlled infusion device.
Dosage Information: (See Table 7.)

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Dosage Adjustment: Due to possible pharmacodynamic interactions, a reduction in dosage of Precedex or other concomitant anesthetics, sedatives, hypnotics or opioids may be required when co-administered [see Anesthetics, Sedatives, Hypnotics, Opioids under Interactions].
Dosage reductions may need to be considered for patients with renal or hepatic impairment, and geriatric patients [see Hepatic Impairment under Precautions and Pharmacology: Pharmacokinetics under Actions].
Preparation of Solution: Precedex must be diluted in 0.9% sodium chloride solution to achieve required concentration (4 mcg/mL) prior to administration. Preparation of solutions is the same, whether for the loading dose or maintenance infusion.
Strict aseptic technique must always be maintained during handling of Precedex.
To prepare the infusion, withdraw 2 mL of Precedex and add to 48 mL of 0.9% sodium chloride injection to a total of 50 mL. Shake gently to mix well.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if product is discolored or if precipitate matter is present.
Administration with Other Fluids: Precedex infusion should not be co-administered through the same intravenous catheter with blood or plasma because physical compatibility has not been established.
Precedex has been shown to be incompatible when administered with the following drugs: amphotericin B, diazepam.
Precedex has been shown to be compatible when administered with the following intravenous fluids: 0.9% sodium chloride in water, 5% dextrose in water, 20% mannitol, Lactated Ringer's solution, 100 mg/mL magnesium sulfate solution and 0.3% potassium chloride solution.
Compatibility with Natural Rubber: Compatibility studies have demonstrated the potential for absorption of Precedex to some types of natural rubber. Although Precedex is dosed to effect, it is advisable to use administration components made with synthetic or coated natural rubber gaskets.