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Mefenamic acid should not be used in patients with known hypersensitivity to mefenamic acid or any of the components of this product.
Because the potential exists for cross-sensitivity to aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), mefenamic acid should not be given to patients in whom these drugs induce symptoms of bronchospasm, allergic rhinitis, or urticaria.
Mefenamic acid is contraindicated in patients with active ulceration or chronic inflammation of either the upper or lower gastrointestinal tract and should be avoided in patients with pre-existing renal disease.
Treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
Patients with severe renal and hepatic failure.
Patients with severe heart failure.
