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Incompatibilities: The concurrent or sequential use of the other neurotoxic and/or nephrotoxic drugs with polymyxin b sulfate, particularly bacitracin, streptomycin, neomycin, kanamycin, gentamicin, tobramycin, amikacin, cephaloridine, paromomycin, viomycin, and colistin should be avoided.
The neurotoxicity of polymyxin b sulfate can result in respiratory paralysis from neuromuscular blockade, especially when the drug is given soon after anesthesia and/or muscle relaxants.
