IV Adult & childn 15,000-25,000 u/kg daily every 12 hr.
Infant Up to 40,000 u/kg daily.
Renal impairment Reduce from 15,000 u/kg downward every 12 hr. Total daily dose: Not to exceed 25,000 u/kg daily.
IM Adult & childn 25,000-30,000 u/kg daily divided at 4-6 hr intervals.
Infant Up to 40,000 u/kg daily.
Intrathecal Adult & childn >2 yr 50,000 u once daily for 3-4 days then 50,000 u once every other day for at least 2 wk after cultures of CSF are -ve & sugar content returned to normal.
Childn <2 yr 20,000 u once daily for 3-4 days or 25,000 u once every other day. Continue 25,000 u once every other day for at least 2 wk after cultures of CSF are -ve & sugar content returned to normal.
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