Cisplatin is contraindicated in patients: With hypersensitivity to cisplatin or other platinum compounds or to any of the excipients;
With pre-existing renal impairment*;
In dehydrated condition (pre- and post-hydration is required to prevent serious renal dysfunction);
With pre-existing hearing impairment*;
With neuropathy caused by cisplatin;
Who are breast-feeding;
In combination with live vaccines, including yellow fever vaccine;
In combination with phenytoin in prophylactic use.
* Due to the fact that cisplatin is nephrotoxic and neurotoxic (in particular ototoxic). These toxicities may be cumulative if disorders of this type pre-exist.