Adult Take the 1st dose during the evening pre-op & the 2nd dose, the next day during the morning pre-op, or the 1st dose during the afternoon or early evening pre-op & the 2nd dose, 6 hr later during the evening pre-op. Childn Take the 1st dose 8 am pre-op & the 2nd dose 6-8 hr later. ≥9 yr Adult dose, 4-9 yr 1 sachet in the morning & ½ sachet in the afternoon, 2-4 yr ½ sachet in the morning & in the afternoon, 1-2 yr ¼ sachet in the morning & in the afternoon.
May be taken with or without food: Dissolve in 150 mL cold water & stir for 2-3 min.
Contraindications
Hypersensitivity. Congestive cardiac failure, gastric retention, GI ulceration, toxic colitis & megacolon, ileus, severe nausea & vomiting, acute appendicitis, known or suspected GI obstruction or perforation, severe dehydration, rhabdomyolysis, hypermagnesemia, active inflammatory bowel disease. Severe renal impairment.
Elective, open colorectal surgery, recent GI surgery, heart disease, inflammatory bowel disease. Patients on water &/or electrolyte balance-affecting drugs eg diuretics, corticosteroids, lithium; patients on antiepileptics w/ previously controlled epilepsy. Fluid & electrolyte imbalance in patients w/ signs or symptoms of hypokalaemia or hyponatremia. Avoid drinking water only to replace fluid loss. Bowel cleansing should not exceed 24 hr. Patients under controlled K diet. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Not to be used as a routine laxative. Renal impairment. Pregnancy & lactation. Childn. Elderly & debilitated patients.
May modify absorption of other orally administered drugs. Take tetracycline & fluoroquinolone antibiotics, Fe, digoxin, chlorpromazine & penicillamine at least 2 hr before & not <6 hr after administration to avoid chelation w/ Mg. Lowered efficacy by bulk-forming laxatives. Increased risk of water retention &/or electrolyte imbalance w/ NSAIDs or drugs inducing SIADH eg TCAs, SSRIs, antipsychotic drugs & carbamazepine.
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