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Doxazosin is highly bound to plasma proteins (98%). In vitro data in human plasma indicates that Doxazosin has no effect on protein binding of the drugs tested (Digoxin, Phenytoin, Warfarin or Indomethacin). No adverse drug interactions have been observed with thiazide diuretics, furosemide, beta-blocking agents, non-steroidal anti-inflammatory drugs, antibiotics, oral hypoglycemic drugs, uricosuric agents, or anticoagulants.
Concomitant administration of an alpha-blocker with a PDE-5 inhibitor may lead to a symptomatic hypotension in some patients.
