Pencor Dosage/Direction for Use

Oral.
Hypertension: Pencor is used in a once daily regimen: the initial dose is 1 mg, to minimize the potential for postural hypotension and/ or syncope.
Dosage may then be increased to 2 mg after an additional one or two weeks of therapy and thereafter, if necessary to 4 mg. The majority of patients who respond to Pencor will do so at a dose of 4 mg or less. Dosage can be further increased if necessary to 8 mg or the maximum recommended dose of 16 mg.
Benign prostatic hyperplasia: The recommended initial dosage of Pencor is 1 mg given once daily to minimize the potential for postural hypotension and/or syncope. Depending on the individual patient's urodynamics and BPH symptomatically dosage may then be increased to 2 mg and thereafter to 4 mg and up to the maximum recommended dose of 8 mg. The recommended titration interval is 1-2 weeks. The usual recommended dose is 2-4 mg daily.
Children: The safety and efficacy of Pencor in children have not been established.
Elderly: Normal adult dosage.
Patients with renal impairment: Since there is no change in pharmacokinetics in patients with impaired renal function, the usual adult dose of Pencor is recommended.
Pencor is not dialyzable.
Patients with hepatic impairment: There are only limited data in patients with liver impairment and on the effect of drugs known to influence hepatic metabolism (e.g. Cimetidine). As with any drug wholly metabolized by the liver, Pencor should be administered with caution to patients with evidence of impaired liver function