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General: Although there is no evidence of rebound seizures with gabapentin, abrupt withdrawal of anticonvulsants in epileptic patients may precipitate status epilepticus.
Gabapentin is not generally considered effective in the treatment of absence seizures.
Patients who require concomitant treatment with morphine may experience increases in gabapentin concentrations.
Patients should be carefully observed for signs of CNS depression, such as somnolence, and the doses of gabapentin or morphine should be reduced appropriately.
Information for Patients: To assure safe and effective use of gabapentin, the following information and instructions should be given to patients: Inform the physician about any prescription or nonprescription medications, alcohol or drugs the patient is currently taking or planning to take during treatment with gabapentin.
The patient should inform the physician if the patient is pregnant, or if the patient is planning to become pregnant, or if the patient becomes pregnant while they are taking gabapentin.
Gabapentin is excreted in human milk, and the effect on the nursing infant is unknown. The patient should inform the physician if they are breast feeding an infant.
The patient should not allow more than 12 hours between gabapentin doses to prevent breakthrough convulsions.
Effects on the ability to drive or operate machinery: Gabapentin may impair the patient's ability to drive a car or operate potentially dangerous machinery. Patients should be advised not to drive a car or operate potentially dangerous machinery. Until it is known that this medication does not affect their ability to engage in these activities, do not drive a car or operate potentially dangerous machinery.
