Notrixum Adverse Reactions

Associated with the use of Notrixum, there have been reports of skin flushing, mild transient hypotension or bronchospasm, which have been attributed to histamine release.
Very rarely, severe anaphylactoid reactions have been reported in patients receiving Notrixum in conjunction with one or more anesthetic agents.
There have been some reports of seizures in ICU patients who have been receiving Atracurium concurrently with several other agents. These patients usually had one or more medical conditions predisposing to seizures (e.g. cranial trauma, cerebral edema, viral encephalitis, hypoxic encephalopathy, uraemia). In clinical trials, there appears to be no correlation between plasma laudanosine concentration and the occurrence of seizures. There have been some reports of muscle weakness and/or myopathy following prolonged use of muscle relaxants in severely ill patients in the ICU. Most patients were receiving concomitant corticosteroids. These events have been seen infrequently in association with Notrixum. A causal relationship has not been established.