Notrixum Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Atracurium besylate

Indications/Uses

Adjunct to general anesth to enable tracheal intubations & to relax skeletal muscles during surgery or controlled ventilation; to facilitate mechanical ventilation in ICU patients.

Click to view Notrixum detailed prescribing information

Dosage/Direction for Use

Adult 0.3-0.6 mg/kg IV inj depending on duration of full block required or 0.3-0.6 mg/kg initial bolus dose, maintained as continuous infusion at rates 0.3-0.6 mg/kg/hr. Endotracheal intubation: 0.5-0.6 mg/kg IV inj. Childn >1 mth Adult dose. CV disease patient Initial dose should be administered over 60 sec. ICU patient Optional initial bolus dose 0.3-0.6 mg/kg, maintained as continuous infusion at rates between 0.65-0.78 mg/kg/hr.

Click to view Notrixum detailed prescribing information

Overdosage

View Notrixum overdosage for action to be taken in the event of an overdose.

Contraindications

Hypersensitivity.

Click to view Notrixum detailed prescribing information

Special Precautions

History of hypersensitivity to effects of histamine. Myasthenia gravis, other forms of neuromuscular disease & severe electrolyte imbalance, hypovolaemic, burn patients. Pregnancy & lactation.

Click to view Notrixum detailed prescribing information

Use In Pregnancy & Lactation

Click to view Notrixum detailed prescribing information

Adverse Reactions

Skin flushing, mild transient hypotension or bronchospasm.

Click to view Notrixum detailed prescribing information

Drug Interactions

Increased neuromuscular blockade by inhalation anesth eg, halothane, isoflurane, enflurane. Increased magnitude &/or duration of nondepolarizing neuromuscular blockade w/ aminoglycosides, polymyxins, spectinomycin, tetracyclines, lincomycin, clindamycin; propranolol, Ca-channel blockers, lignocaine, procainamide, quinidine; furosemide, mannitol, thiazide diuretics, acetazolamide; Mg sulfate, ketamine, lithium salts; trimetaphan, hexamethonium. May aggravate or unmask latent myasthenia gravis w/ β-blockers, antiarrhythmics, antirheumatics, trimetaphan, chlorpromazine, steroids, phenytoin, lithium. Lengthened onset & shortened duration of nondepolarizing neuromuscular block by chronic anticonvulsant therapy.

Click to view Notrixum detailed prescribing information

Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Notrixum detailed prescribing information

Storage

View Notrixum storage conditions for details to ensure optimal shelf-life.

Action

View Notrixum mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Neuromuscular Blocking Agents

ATC Classification

M03AC04 - atracurium ; Belongs to the class of other quaternary ammonium-containing agents used as peripherally-acting muscle relaxants.

Regulatory Classification

Presentation/Packing

Form

Notrixum soln for inj (amp) 10 mg/mL

Packing/Price

2.5 mL x 5 × 1's;5 mL x 5 × 1's

Notrixum

atracurium besilate

Manufacturer:

Novell Pharma

Distributor:

Averroes Pharma