Side effects are more common during the first months of initial intake of norethisterone preparations, and subside with duration of treatment. The common side effects are uterine/vaginal bleeding including spotting, hypo-menorrhoea and amenorrhoea (in the treatment of endometriosis), headache, nausea, and oedema. Uncommon side effects include migraine and rarely hypersensitivity reactions, urticaria, rash, visual disturbances and dyspnoea. Dizziness, aggravation of depression, abdominal pain and cholestasis jaundice are also known to have occurred.
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