IV infusion Administer doses ≤500 mg over 20-30 min & >500 mg over 40-60 min. Max: 4 g daily.
Infection w/ full susceptibility Adult w/ CrCl ≥90 mL/min 500 mg every 6 hr or 1,000 mg every 8 hr,
60-90 mL/min 400 or 500 mg every 6 hr,
30-60 mL/min 300 mg every 6 hr or 500 mg every 8 hr,
15-30 mL/min & hemodialysed patient w/ CrCl <15 mL/min 200 mg every 6 hr or 500 mg every 12 hr.
Intermediate susceptibility Adult w/ CrCl ≥90 mL/min 1,000 mg every 6 hr,
60-90 mL/min 750 mg every 8 hr,
30-60 mL/min 500 mg every 6 hr,
15-30 mL/min & hemodialysed patient w/ CrCl <15 mL/min 500 mg every 12 hr.
Non-CNS infections Ped ≥3 mth 15-25 mg/kg every 6 hr,
4 wk-3 mth 25 mg/kg every 6 hr,
1-4 wk 25 mg/kg every 8 hr,
<1 wk 25 mg/kg every 12 hr. Max: 4 g daily.
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