Nimbex Caution For Usage

Incompatibilities: NIMBEX is not chemically stable when diluted with Lactated Ringer's Injection.
Since NIMBEX is stable only in acidic solutions, it should not be mixed in the same syringe or administered simultaneously through the same needle with alkaline solutions, e.g. sodium thiopentone. It is not compatible with ketorolac trometamol or propofol injectable emulsion.
NIMBEX has been shown to be compatible with the following commonly used peri-operative drugs, when mixed in conditions simulating administration into a running i.v. infusion via a Y- site injection port: alfentanil hydrochloride, droperidol, fentanyl citrate, midazolam hydrochloride and sufentanil citrate. Where other drugs are administered through the same indwelling needle or cannula as NIMBEX, it is recommended that each drug be flushed through with an adequate volume of a suitable i.v. fluid, e.g., sodium chloride i.v. infusion 0.9% (w/v).
As with other drugs administered intravenously, when a small vein is selected as the injection site, NIMBEX should be flushed through the vein with a suitable i.v. fluid, e.g., sodium chloride i.v. infusion (0.9% w/v).
Instructions for Use/Handling: Diluted NIMBEX is physically and chemically stable for at least 24 hours between 5°C and 25°C at concentrations between 0.1 and 2.0 mg/mL in the following infusion fluids, in either polyvinyl chloride (PVC) or polypropylene: sodium chloride (0.9% w/v) i.v. infusion; dextrose/glucose (5% w/v) i.v. infusion; sodium chloride (0.18% w/v) and dextrose (4% w/v) I.V. infusion; sodium chloride (0.45% w/v) and dextrose (2.5% w/v) I.V. infusion.
However, since the product contains no antimicrobial preservative dilution should be carried out immediately prior to use, administration should commence as soon as possible thereafter and any remaining solution should be discarded.