NeoMercazole Dosage/Direction for Use

For oral administration only.
NeoMercazole should only be administered if hyperthyroidism has been confirmed by laboratory tests.
Adults: The initial dose is in the range 20-60 mg, and should be titrated against thyroid function until the patient is euthyroid in order to reduce the risk of over-treatment and resultant hypothyroidism. Subsequent therapy may then be administered in one of two ways.
Maintenance regimen: Final dosage is usually in the range 5-15 mg per day, which may be taken as a single daily dose. Therapy should be continued for at least six, and up to eighteen months. Serial thyroid function monitoring is recommended, together with appropriate dosage modification in order to maintain a euthyroid state.
Blocking-replacement regimen: Dosage is maintained at the initial level, i.e. 20-60 mg per day, and supplemental l-thyroxine, 50-150 mcg per day, is administered concomitantly, in order to prevent hypothyroidism. Therapy should be continued for at least six months, and up to eighteen months.
Elderly: No special dosage regimen is required, but care should be taken to observe the contraindications and warnings as it has been reported that the risk of a fatal outcome to neutrophil dyscrasia may be greater in the elderly (aged 65 or over).
Children: The usual initial daily dose is 15 mg per day.