Decreased plasma conc w/ P-gp inducers eg, rifampicin, rifabutin, carbamazepine, phenobarb or St. John's wort. Increased plasma conc w/ P-gp or BCRP inhibitors. Decreased C
max w/ carbamazepine, oxcarbazepine, phenobarb, phenytoin, rifampicin, rifapentine, rifabutin, tipranavir/ritonavir, efavirenz, St. John's wort (
Hypericum perforatum). Increased C
max w/ itraconazole, ketoconazole, sofosbuvir/velpatasvir, sofosbuvir/velpatasvir/voxilaprevir, atazanavir/cobicistat, atazanavir/ritonavir, darunavir/ritonavir, lopinavir/ritonavir, dolutegravir.