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Pharmacology: Pharmacodynamics: Mupirocin is a topical antibacterial agent, active against those organisms responsible for the majority of skin infections eg, Staphylococcus aureus including methicillin-resistant strains, other staphylococci and streptococci. It is also active against gram-negative pathogens eg, Escherichia coli and Haemophilus influenzae.
Pharmacokinetics: Mupirocin penetrates intact human skin but the rate of systemic absorption appears to be low. Systemically absorbed mupirocin is rapidly metabolised to the inactive metabolite monic acid and quickly excreted by the kidneys.
