Rebamipide had little inhibitory effect on cytochrome P450 enzymes in vitro. Rebamipide is hardly metabolized in the liver and excreted in urine as an unchanged compound; thus, the drug has not much influence on metabolization of other drugs. Regarding the concomitant administration with other drugs with higher protein binding rats (H2 blocker and Warfarin), although Mucosta (rebamipide) has a high protein binding rate (95% or more), its blood concentration is as low as up to 200 ng/mL; therefore, this drug is considered less likely to increase the blood concentration in competition with other drugs. In addition, there have been reports that Mucosta (rebamipide) has not been influenced by (1) plasma salicylic acid concentration (human) at the time of aspirin administration, (2) serum indomethacin concentration (human) at the time of indomethacin administration, and (3) plasma and tumor tissue 5-FU concentration (rat) at the time of UFT administration. No drug interactions between rebamipide and other drugs are reported.
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