Minirin Overdosage

Toxicity: Overdosage leads to prolonged duration of action with an increased risk of fluid retention and hyponatraemia. Even normal doses may in combination with considerable fluid intake cause water intoxication. Doses from 0.3 mcg/kg i.v. and 2.4 mcg/kg intranasally have caused hyponatraemia and convulsions in children and adults. On the other hand, 40 mcg intranasally administered to a 5-month-old baby and 80 mcg intranasally to a 5-year-old gave no symptoms. 4 mcg administered parenterally to a newborn caused oliguria and weight gain.
Symptoms: The same symptoms as for water intoxication. Headache, nausea. Fluid retention, hyponatraemia, hypoosmolality, oliguria, CNS depression, convulsions, pulmonary oedema. See also side-effects described as previously mentioned.
Treatment: The treatment of hyponatraemia should be individual but the following general recommendations may be given: Hyponatraemia is treated by interrupting the desmopressin treatment and fluid restriction. If the patient has symptoms an infusion of isotonic or hypertonic sodium chloride may be given. When the fluid retention is serious (convulsions and loss of consciousness) furosemide treatment is given.