Not to be initiated in patients suffering from other conditions increasing fluid or electrolyte imbalance. Interrupt treatment in acute illness characterised by fluid &/or electrolye imbalance eg, systemic infections, fever, gastroenteritis. Urgency/urge incontinence, organic causes for increased micturition frequency or nocturia (eg, benign prostatic hyperplasia, UTI, bladder stone/tumor), polydipsia, poorly adjusted DM; increased intracranial pressure. Risk of hyponatraemia in patients w/ low serum Na levels & high 24-hr urine vol. Limit fluid intake to least possible during period of 1 hr before until at least 8 hr after administration for primary nocturnal enuresis & nocturia. Monitor fluid restriction & serum Na in concomitant use w/ drugs inducing SIADH eg, TCAs, SSRIs, chlorpromazine, carbamazepine & NSAIDs. Pregnancy & lactation. Not to be used in elderly >65 yr.
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