Melomet Mechanism of Action

Pharmacotherapeutic group: Mometasone.
Pharmacology: Pharmacodynamics: Cream: Mometasone furoate, a synthetic corticosteroid, exhibits marked anti-inflammatory, antipruritic and vasoconstrictive properties. Although generally unclear, corticosteroids are thought to act by the induction of phospholipase A₂ inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A₂.
Lotion: Mometasone furoate exhibits marked anti-inflammatory activity and marked anti-psoriatic activity in standard animal predictive models.
Pharmacokinetics: Pharmacokinetic studies have indicated that systemic absorption following topical application of mometasone furoate cream and ointment 0.1% is minimal, approximately 0.4% and 0.7% respectively, of the applied dose in man, the majority of which is excreted within 72 hours following application. Characterization of metabolites is not significant owing to the small amounts present in plasma and excreta.
Lotion: Minimal absorption would be anticipated with the lotion formulation.