Malarone Dosage/Direction for Use

The daily dose should be taken with food or a milky drink at the same time each day.
In the event of vomiting within 1 hour of dosing a repeat dose should be taken.
Prophylaxis: Prophylaxis should start 1 or 2 days before entering a malaria-endemic area, and be continued daily until 7 days after leaving the area.
Dosage in Adults: One Malarone tablet (250 mg atovaquone/100 mg proguanil) daily.
Dosage in Children: Greater than 40 kg body-weight - One MALARONE tablet daily.
Treatment: Dosage in Adults: Four MALARONE tablets (total daily dose 1 g atovaquone/400 mg proguanil hydrochloride) as a single dose for three consecutive days.
Dosage in Children: (See table.)

Click on icon to see table/diagram/image

Use in Children below 11 kg: The usage has not been established.
Dosage in the Elderly (Prophylaxis and Treatment): A pharmacokinetic study indicates that no dosage adjustments are needed in the elderly (see Pharmacology: Pharmacokinetics under Actions).
Dosage in Renal Impairment (Prophylaxis and Treatment): Pharmacokinetic studies indicate that no dosage adjustments are needed in patients with mild to moderate renal impairment. In patients with severe renal impairment (creatinine clearance less than 30 mL/min) alternatives to MALARONE should be recommended for treatment of acute P. falciparum malaria whenever possible (see Precautions and Pharmacology: Pharmacokinetics under Actions). For prophylaxis of P. falciparum malaria in patients with severe renal impairment, see Contraindications.
Dosage in Hepatic Impairment (Prophylaxis and Treatment): A pharmacokinetic study indicates that no dosage adjustments are needed in patients with mild to moderate hepatic impairment. No studies have been conducted in patients with severe hepatic impairment (see Pharmacology: Pharmacokinetics under Actions).