Prophylaxis Start 1-2 days before entering malaria-endemic area & continue daily until 7 days after leaving the area. Adult & childn >40 kg 1 tab daily. TreatmentAdult & childn >40 kg 4 tab as single dose for 3 consecutive days. Childn 31-40 kg 3 tab as single dose for 3 consecutive days, 21-30 kg 2 tab as single dose for 3 consecutive days, 11-20 kg 1 tab as single dose for 3 consecutive days.
Not for treatment of cerebral malaria or other severe manifestations of complicated malaria eg, hyperparasitaemia, pulmonary oedema or renal failure. Recrudescent infections due to P falciparum or failure of chemoprophylaxis; travellers w/ intense exposure to P vivax or P ovale & those who develop malaria caused by either of these parasites. Monitor parasitaemia in patients receiving metoclopramide or tetracycline. Not recommended w/ concomitant rifampicin or rifabutin. Severe renal impairment. Pregnancy. Not recommended during lactation. Paed patients <11 kg.
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