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Hypersensitivity reactions (such anaphylactic reaction, angioedema and serum sickness) have been reported, some of these in patients known to be sensitive to penicillin. If an allergic reaction should occur, the drug should be discontinued and the usual agents (adrenaline, corticosteroids, antihistamines) should be available for emergency treatment.
In patients with impaired hepatic or renal function, the serum half-life of Lincomycin is increased. Consideration should be given to decreasing the frequency and dose of Lincomycin administered in patients with impaired hepatic or liver function. Since adequate data are not yet available in patients with pre-existing liver disease, its use in such patients is not recommended at this time unless special clinical circumstances so indicate.
