UTI; thrombocytopenia, lymphopenia, leukopenia, neutropenia; hypothyroidism; increased blood TSH; hypocalcaemia, hypercholesterolaemia, hypokalaemia, hypomagnesaemia, decreased appetite & wt, dehydration; insomnia; dizziness, headache, dysgeusia; haemorrhage, HTN, hypotension; dysphonia; diarrhoea, GI & abdominal pain, vomiting, nausea, oral inflammation & pain, constipation, dyspepsia, dry mouth, increased lipase & amylase; increased blood bilirubin & alkaline phosphatase, ALT, AST & γ-glutamyltransferase, hypoalbuminaemia; palmar-plantar erythrodysaesthesia syndrome, rash, alopecia; back pain, arthralgia, myalgia, pain in extremity, musculoskeletal pain; proteinuria, increased blood creatinine; fatigue, asthenia, peripheral oedema. Dehydration; MI, ECG prolonged QT; pulmonary embolism; flatulence; abnormal hepatic function, cholecystitis; hyperkeratosis; renal failure, increased blood urea; malaise. Monotherapy/combination w/ everolimus: CVA; cardiac failure, decreased ejection fraction; anal fistula; hepatic failure & encephalopathy; palmar erythema; renal impairment. Combination w/ pembrolizumab: Anaemia; hyperthyroidism; pancreatitis, colitis.