Hypersensitivity to the active substance, or to any of the excipients (see Description).
Human Immunodeficiency Virus (HIV) infection.
Patients with severe active infection until complete resolution.
Patients with uncontrolled hypertension.
Patients with a history of arterial dissection of the cervicocephalic arteries.
Patients with a history of stroke.
Patients with a history of angina pectoris or myocardial infarction.
Patients with known coagulopathy, on anti-platelet or anti-coagulant therapy.
Patients with other concomitant autoimmune diseases (besides MS).