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Adult and elderly patients: The recommended dose of letrozole is 2.5 mg once daily. In the adjuvant and extended adjuvant setting, treatment with letrozole should continue for 5 years or until tumor relapse occurs, whichever comes first. In patients with metastatic disease, treatment with letrozole should continue until tumor progression is evident. No dose adjustment is required for elderly patients.
Children: Not applicable.
Patients with hepatic and/or renal impairment: No dosage adjustment is required for patients with hepatic impairment or renal impairment (creatinine clearance ≥10 mL/min.). However, patients with severe hepatic impairment (Child-Pugh score C) should be kept under close supervision.
Route of Administration: Oral.
