Lebreta

Lebreta

letrozole

Manufacturer:

Duopharma HAPI

Distributor:

Duopharma HAPI
Concise Prescribing Info
Contents
Letrozole
Indications/Uses
Adjuvant treatment of postmenopausal women w/ hormone-receptor +ve early breast cancer; early breast cancer (+ve or unknown oestrogen or progesterone-receptor status) who have received 5 yr adjuvant tamoxifen therapy (extended adjuvant therapy). 1st-line treatment in postmenopausal women w/ hormone-dependent advanced breast cancer. Advanced breast cancer in women w/ natural- or artificially-induced postmenopausal status who have previously been treated w/ antioestrogens. Pre-op therapy in postmenopausal women w/ localised hormone-receptor +ve breast cancer.
Dosage/Direction for Use
Adult& elderly 2.5 mg once daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Premenopausal endocrine status. Pregnancy & lactation.
Special Precautions
Osteoporosis &/or bone fractures. May affect ability to drive & use machines. Renal & severe hepatic impairment. Women of perimenopausal status or childbearing potential. Not to be used in childn.
Adverse Reactions
Arthralgia; hot flushes; nausea; fatigue. Leukopenia; anorexia, increased appetite, hypercholesterolemia; depression; headache, dizziness; vomiting, dyspepsia, constipation, diarrhoea; alopecia, increased sweating including erythematous, maculopapular psoriaform & vesicular rash; myalgia, bone pain & fractures, osteoporosis, arthritis; asthenia, malaise, peripheral oedema; increased wt.
Drug Interactions
MIMS Class
Cancer Hormone Therapy
ATC Classification
L02BG04 - letrozole ; Belongs to the class of enzyme inhibitors. Used in treatment of neoplastic diseases.
Presentation/Packing
Form
Lebreta tab 2.5 mg
Packing/Price
3 × 10's
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