Adult >16 yr Epilepsy monotherapy Initially 25 mg once daily for 2 wk, followed by 50 mg once daily for 2 wk. May be increased by 50-100 mg every 1-2 wk. Maintenance: 100-200 mg once daily or in 2 divided doses.
Adult >12 yr Add-on therapy w/ valproate Initially 25 mg every alternate day for 2 wk, followed by 25 mg once daily for 2 wk. May be increased by 25-50 mg every 1-2 wk. Maintenance: 100-200 mg once daily or in 2 divided doses.
Add-on therapy w/ antiepileptics or other medications inducing lamotrigine glucuronidation Initially 50 mg once daily for 2 wk, followed by 100 mg daily in 2 divided doses for 2 wk. May be increased by 100 mg every 1-2 wk. Maintenance: 200-400 mg daily in 2 divided doses.
Add-on therapy w/ drugs that do not significantly inhibit or induce lamotrigine glucuronidation Initially 25 mg once daily for 2 wk, followed by 50 mg once daily for 2 wk. May be increased by 50-100 mg every 1-2 wk. Maintenance: 100-200 mg once daily or in 2 divided doses.
Childn 2-12 yr Add-on therapy w/ valproate Initially 0.15 mg/kg once daily for 2 wk, followed by 0.3 mg/kg once daily for 2 wk. May be increased by 0.3 mg/kg every 1-2 wk. Maintenance: 1-5 mg/kg once daily or in 2 divided doses. Max: 200 mg daily.
Add-on therapy w/ antiepileptics or other medications inducing lamotrigine glucuronidation Initially 0.6 mg/kg daily in 2 divided doses for 2 wk, followed by 1.2 mg/kg daily in 2 divided doses for 2 wk. May be increased by 1.2 mg/kg every 1-2 wk. Maintenance: 5-15 mg/kg daily in 2 divided doses. Max: 400 mg daily.
Add-on therapy w/ drugs that do not significantly inhibit or induce lamotrigine glucuronidation Initially 0.3 mg/kg once daily or in 2 divided doses for 2 wk, followed by 0.6 mg/kg once daily or in 2 divided doses for 2 wk. May be increased by 0.6 mg/kg every 1-2 wk. Maintenance: 1-10 mg/kg once daily or in 2 divided doses. Max: 200 mg daily.
Adult ≥18 yr Bipolar disorder adjunct therapy w/ valproate Initially 25 mg every alternate day for 2 wk, followed by 25 mg once daily for 2 wk. May be increased to 50 mg once daily or in 2 divided doses for 1 wk. Usual target dose: 100 mg once daily or in 2 divided doses, may be increased to max: 200 mg daily.
Adjunct therapy w/ phenytoin, carbamazepine, phenobarb, primidone & other drugs inducing lamotrigine glucuronidation Initially 50 mg once daily for 2 wk, followed by 100 mg daily in 2 divided doses for 2 wk. May be increased to 200 mg daily in 2 divided doses for 1 wk, then further increased to 300 mg daily for 1 wk. Usual target dose: 400 mg daily in 2 divided doses for 1 wk.
Monotherapy or adjunct therapy w/ drugs that do not significantly induce or inhibit lamotrigine glucuronidation Initially 25 mg once daily for 2 wk, followed by 50 mg once daily or in 2 divided doses for 2 wk. May be increased to 100 mg once daily or in 2 divided doses for 1 wk. Usual target dose: 200 mg once daily or in 2 divided doses.