Kytron Drug Interactions

The metabolism of Granisetron is induced by phenobarbital.
Avoid concomitant use of Granisetron with Apomorphine as Granisetron may increase Apomorphine levels/effect.
Kytron Solution for Injection/Infusion 3 mg/3 ml has been safely administered with benzodiazepines, neuroleptics, and anti-ulcer medications commonly prescribed with anti-emetic treatments. Additionally, Kytron Solution for Injection/Infusion has shown no apparent drug interaction with emetogenic cancer chemotherapies. As for other 5-HT3 antagonists, cases of ECG modifications including QT prolongation have been reported with Kytron Solution for Injection/Infusion. The ECG changes with Kytron Solution for Injection/Infusion were minor, generally not of clinical significance and specifically, there was no evidence of proarrhythmia. However, in patients concurrently treated with drugs known to prolong QT interval and/or are arrhythmogenic, this may lead to clinical consequences. As with other 5-HT3 antagonists, cases of serotonin syndrome have been reported following the concomitant use of Kytron Solution for Injection/Infusion and other serotonergic drugs. If concomitant treatment with granisetron and other serotonergic drugs is clinically warranted, appropriate observation of the patient is advised.
Kytron Solution for Injection/Infusion 3 mg/3 ml cannot be diluted with other diluent except stated in Preparing the Solution with Compatible Diluent under Storage.