Kytril Caution For Usage

Incompatibilities: Admixtures of granisetron hydrochloride and dexamethasone sodium phosphate are compatible at concentrations of 10 to 60 mcg/ml granisetron and 80 to 480 mcg/ml dexamethasone phosphate in either 0.9% sodium chloride or 5% glucose intravenous infusion fluids.
The admixture will have a shelf-life of 24 hours.
Instructions for Use, Handling and Disposal: Preparation of Infusion: For adults: The appropriate dose is diluted with infusion fluid, to a total volume of 20 to 50ml in any of the following solutions: 0.9% sodium chloride, 0.18% sodium chloride and 4% dextrose, 5% dextrose, Hartmann's solution, sodium lactate and mannitol.
For children: The appropriate dose is diluted with infusion fluid (as for adults) to a total volume of 10 to 30ml.
Kytril has been shown to be stable for at least 24 hours when stored at ambient temperature in any of the following solutions: 0.9% sodium chloride, 0.18% sodium chloride and 4% dextrose, 5% dextrose, Hartmann's solution, sodium lactate and mannitol.
From a microbiological point of view the diluted product should be used immediately. If not used immediately, in use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 h at 2°C - 8°C, unless dilution has taken place in controlled and validated aseptic conditions.