Kytril

Kytril

granisetron

Manufacturer:

Atnahs Pharma

Distributor:

DKSH
Concise Prescribing Info
Contents
Granisetron
Indications/Uses
Prevention & treatment of acute & delayed nausea & vomiting associated w/ chemotherapy & RT (CINV & RINV). Inj: Prevention & treatment of post-op nausea & vomiting (PONV).
Dosage/Direction for Use
Tab Adult CINV prevention 1 mg bd or 2 mg once daily for up to 1 wk following chemotherapy, 1st dose w/in 1 hr before therapy. RINV 2 mg once daily for up to 1 wk following RT, 1st dose w/in 1 hr before therapy. Inj Adult CINV 1-3 mg slow IV inj over 30 sec or IV infusion over 5 min prior to chemotherapy. Max dose: 9 mg/24 hr. RINV prevention 1-3 mg slow IV inj over 30 sec or as IV infusion over 5 min prior to RT. PONV prevention 1 mg slow IV inj over 30 sec prior to anesth induction. PONV treatment 1 mg slow IV inj over 30 sec. Max dose: 3 mg daily. Childn CINV 10-40 mcg/kg IV infusion over 5 min prior to chemotherapy, may administer 1 additional dose w/in 24 hr at least 10 min after initial infusion.
Administration
Tab: May be taken with or without food.
Contraindications
Special Precautions
Subacute intestinal obstruction, preexisting arrhythmias or cardiac conduction disorders, cardiac co-morbidities; concomitant electrolyte abnormalities. Cross-sensitivity w/ other 5-HT3 antagonists. Concomitant use w/ cardiotoxic chemotherapy; other serotonergic drugs. Not to be taken by patients w/ galactose intolerance, lactase deficiency or glucose-galactose malabsorption. Pregnancy & lactation.
Adverse Reactions
Headache; constipation. Elevated hepatic transaminases.
Drug Interactions
Increased total plasma clearance w/ phenobarb. Serotonin syndrome w/ other serotonergic drugs. Drugs prolonging QT interval &/or are arrhythmogenic.
MIMS Class
Antiemetics / Supportive Care Therapy
ATC Classification
A04AA02 - granisetron ; Belongs to the class of serotonin (5HT3) antagonists. Used for the prevention of nausea and vomiting.
Presentation/Packing
Form
Kytril FC tab 1 mg
Packing/Price
10's
Form
Kytril soln for inj 1 mg/mL
Packing/Price
5 × 1's
Form
Kytril soln for inj 3 mg/3 mL
Packing/Price
5 × 1's
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in