Kryxana Description

Tablet: 200 mg ribociclib (equivalent to 254.40 mg ribociclib succinate).
KRYXANA (ribociclib) is a kinase inhibitor.
The chemical name of ribociclib succinate is: Butanedioic acid-7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl) pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (1/1).
Ribociclib succinate is a light yellow to yellowish brown crystalline powder. The molecular formula for ribociclib succinate is C₂₃H₃₀N₈O·C₄H₆O₄ and the molecular weight is 552.64 g/mol (Free base: 434.55 g/mol).
KRYXANA film-coated tablets are supplied for oral use and contain 200 mg of ribociclib free base (equivalent to 254.40 mg ribociclib succinate).
The tablets also contain colloidal silicon dioxide, crospovidone, hydroxypropylcellulose, magnesium stearate and microcrystalline cellulose. The film-coating contains iron oxide black, iron oxide red, lecithin (soya), polyvinyl alcohol (partially hydrolysed), talc, titanium dioxide, and xanthan gum as inactive ingredients.