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Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients on penicillin therapy. Anaphylaxis is more frequent following parenteral therapy than oral penicillins. These reactions are more apt to occur in individuals with a history of sensitivity to multiple allergens.
Penicillin Hypersensitivity: These are cross-allerginicity between ampicillin and other penicillins, so that patients with a history of penicillin allergy may respond similarly to Ampicillin. Cross-allergenicity also occurs between penicillins and cephalosporins in a proportion of patients.
