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Incompatibility: Extemporaneous admixtures of beta-lactam antibacterials (penicillins and cephalosporins) and aminoglycosides may result in substantial mutual inactivation. If these groups of antibacterials are administered concurrently, they should be administered in separate sites at least 1 hour apart. Do not mix them in the same intravenous bag, bottle or tubing.
When aminoglycosides and penicillins are administered separately by different routes, a reduction of aminoglycoside serum concentration may impaired renal function when excretion of both medications is delayed.
