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Women of child-bearing potential/contraception: IZBA eye drops must not be used in women of child bearing age/potential unless adequate contraceptive measures are in place (see Pharmacology: Toxicology: Preclinical safety data under Actions).
Pregnancy: Travoprost has harmful pharmacological effects on pregnancy and/or the foetus/new-born child. IZBA eye drops should not be used during pregnancy unless clearly necessary.
Breast-feeding: It is unknown whether travoprost from eye drops is excreted in human breast milk. Animal studies have shown excretion of travoprost and metabolites in breast milk.
The use of IZBA eye drops by breast-feeding mothers is not recommended.
Fertility: There are no data on the effects of travoprost on human fertility. Animal studies showed no effect of travoprost on fertility at doses more than 250 times the maximum recommended human ocular dose.
