Ixazomib is used together with other medicines to treat cancer of the blood that affects the bone marrow.
Take Ixazomib exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
Take it at least 1 hour before or 2 hours after a meal.
Swallow the capsule whole with a glass of water. Do not open, chew or crush the capsule.
If you vomit after taking Ixazomib, do not repeat the dose. Take the next dose at your normal scheduled time.
The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the severity of your condition and your response to the medication.
Ixazomib must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
If you miss a dose, take the dose as long as the next scheduled dose is more than 3 days or 72 hours away. Skip the missed dose if it is within 3 days or 72 hours of your next scheduled dose.
DO NOT double a dose under any circumstances.
If you often forget to take your medicine, let your doctor and pharmacist know.
Do not breastfeed while you are being treated with Ixazomib.
Inform your doctor if you have the following conditions:
- severe kidney disease
- moderate to severe liver disease
It is important that you do not get pregnant while being treated with Ixazomib. You may wish to discuss birth control methods with your doctor or pharmacist.
Why is it important to keep my appointments with the doctor?
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
- Pregnancy tests must be done before treatment to know if this medicine is suited for you to take.
- Routine tests (e.g. liver or kidney function, platelet count, complete blood count) may be done while you are being treated with this medicine. Your doctor will advise you about how often you need to have these tests.
- Regular monitoring of signs of skin reactions and stomach or bowel problems may also be needed.
Ixazomib may cause dizziness or tiredness. If affected, do not drive or take part in any activity in which you need to be alert.
Other side effects include any of the following: nausea, diarrhoea, constipation, vomiting, blurred vision, and back pain.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- swelling of the ankles, feet or hands
- tingling or numbing of the hands and feet
- frequent sore throat, mouth sores, fever, chills or sweating
- unusual bleeding or bruising
- rashes with peeling of the skin or blistering of the lips, mouth or eyes accompanied by fever
- yellowing of the skin or eyes, abdominal pain, dark coloured urine, tiredness, swelling in the legs and ankles
- severe rashes, especially with multiple tiny red or purple spots on the skin and sometimes on the inside of the mouth.
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Inform your doctor and pharmacist if you are taking any of these medicines:
- medicines for epilepsy (fits or seizures) e.g. carbamazepine, phenytoin
- rifampicin (medicine to treat TB [an infection known as tuberculosis])
- St. John's wort (herbal medicine)
This list does not include all medicines that may interact with Ixazomib.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.
Avoid alcohol.
Avoid taking Ixazomib together with high-fat foods as the effectiveness of this medicine may be reduced. Ask your doctor about the types of food you should avoid.
Store in a cool, dry place away from the reach of children.
Medicines must not be used past the expiry date.
As Ixazomib is a cancer medicine, always return any unused or expired capsules to the clinic, hospital, or pharmacy for disposal. Do not throw it away in the household waste.
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