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Investigations: hyperkalaemia, increases in plasma creatine kinase.
Cardiac disorders: tachycardia.
Vascular disorders: orthostatic hypotension, flushing.
Nervous system disorders: headache, dizziness.
Respiratory, thoracic and mediastinal disorders: cough, upper respiratory infection.
Gastrointestinal disorders: nausea, vomiting, diarrhoea, dyspepsia/heartburn, dysgeusia.
General disorders and administration site conditions: fatigue.
Renal and urinary disorders: impaired renal function including cases of renal failure in patients at risk.
Skin and subcutaneous tissue disorders: urticaria, leukocytoclastic vasculitis.
Musculoskeletal and connective tissue disorders: arthralgia, myalgia (in some cases associated with increased plasma creatine kinase levels), rhabdomyolysis, muscle cramps.
Immune system disorders: hypersensitivity reactions such as angioedema, rash, urticaria.
Hepato-biliary disorders: hepatitis, abnormal liver function, cholestasis, jaundice.
Hematologic disorders: thrombocytopenia.
Reproductive system and breast disorders: sexual dysfunction.
Ear and labyrinth disorders: tinnitus.
