Initial & maintenance dose: 150 mg once daily, may be increased to 300 mg or other anti-hypertensive agents can be added. Hypertensive type 2 diabetic patient Initially 150 mg once daily, titrated up to 300 mg once daily as preferred maintenance dose for renal disease treatment. Elderly >75 yr & haemodialysis patient Initially 75 mg.
Not recommended in patients w/ primary aldosteronism. Patients w/ aortic & mitral valve stenosis or obstructive hypertrophic cardiomyopathy; ischaemic cardiopathy or ischaemic CV disease. Hyperkalaemia. Bilateral renal artery stenosis or stenosis of artery to single functioning kidney. Monitor serum K & creatinine levels, electrolytes & BP. Correct vol &/or Na depletion prior to therapy. Not recommended in combination w/ ACE inhibitors, ARBs or aliskiren; lithium. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Black patients. May affect ability to drive & use machines. Renal impairment & recent kidney transplantation. Not recommended during 1st trimester of pregnancy. Lactation. Not recommended in childn & adolescents.
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