Hexidine Side Effects

Immune system disorders: Frequency not known: Hypersensitivity including anaphylactic shock.
A superficial discoloration of the dorsum of the tongue may occur. This disappears after treatment is discontinued. Discoloration of the teeth and silicate or composite restorations may also occur. The stain is not permanent and can largely be prevented by brushing with conventional toothpaste daily before using Hexidine. However, in certain cases of professional prophylaxis (scaling and polishing) may be required to remove the stain completely. Stained anterior tooth coloured restorations with poor margins or rough surfaces, which are not adequately cleaned by professional prophylaxis, may require replacement.
Transient disturbance of taste sensation and a burning sensation of the tongue may occur on initial use of the Hexidine. These effects usually diminish with continued use.
Mouthwash: Irritative skin reactions to chlorhexidine preparations can occasionally occur. Generalized allergic reactions to chlorhexidine have also been reported but are extremely rare.