Glucoxit

Metformin HCl

Monotherapy or adjunct to sulfonylurea for NIDDM when hyperglycemia cannot be controlled by diet management, exercise or wt reduction.

Adult 500 mg tds, may be gradually increased if needed to max: 3 g daily.

Should be taken with food.

Hypersensitivity. Acute metabolic acidosis eg, lactic acidosis, diabetic ketoacidosis; conditions needing blood glucose control eg, severe burns, dehydration, diabetic coma, hyperosmolar nonketotic coma, severe infection, major surgery, severe trauma; shock, pulmonary insufficiency, alcoholism; conditions associated w/ hypoxaemia eg, cardioresp insufficiency, CV collapse, CHF, acute MI. Not be given in patients undergoing diagnostic or medical exam using contrast media eg, angiography, pyelography. Severe renal impairment (GFR <30 mL/min); severe hepatic disease.

Conditions decreasing/delaying stomach emptying eg, diarrhea, gastroparesis, intestinal obstruction, vomiting or conditions causing delayed food absorption; conditions predisposing to hyperglycemia (eg, female hormonal changes, high fever) or hypoglycemia (eg, adrenal insufficiency, debilitated physical conditions, malnutrition); hyperthyroidism; lactic acidosis; inadequately controlled diabetes, ketosis; conditions associated w/ hypoxia. Monitor glucose levels frequently; monitor urine for presence of glucose & ketones if blood glucose levels >200 mg/dL; monitor HbA1c every 3 mth. Determine serum folic acid & vit B₁₂ conc every 1-2 yr during long-term therapy. Assess GFR prior to & at least annually thereafter. Concomitant use w/ drugs impairing renal function eg, antihypertensives, diuretics, NSAIDs; drugs causing lactic acidosis. Prolonged fasting. Excessive alcohol intake. Renal & hepatic insufficiency. Pregnancy & lactation. Ped patients.

Anorexia, dyspepsia, flatulence, headache, metallic taste, nausea, vomiting, wt loss.

Increased risk of developing hypoglycemia w/ alcohol. Increased plasma conc w/ cimetidine; other cationic drugs excreted by renal tubular transport eg, amiloride, Ca-channel blockers, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin. Hyperglycaemia w/ OCs, corticosteroids, diuretics, estrogens, INH, nicotinic acid, phenothiazines, phenytoin, sympathomimetics, thyroid hormones. Hypoglycaemia w/ clofibrate, MAOIs, probenecid, propranolol, rifabutin, rifampicin, salicylates, sulfonamides, sulphonylureas.

Antidiabetic Agents

A10BA02 - metformin ; Belongs to the class of biguanides. Used in the treatment of diabetes.

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