Glice Use In Pregnancy & Lactation

Pregnancy: Developmental toxicity studies performed in rats and rabbits using various routes of administration did not reveal any effect on the embryos, fetuses, or the young animals even at toxic doses for the dam.
Lactation: Available evidence is inconclusive or inadequate for determining infant risk when used during breastfeeding. There is data that nitrates are excreted in breast milk and may cause methemoglobinemia in infants. The extent of excretion of nitroglycerin in human breast milk has not been determined. A risk to the suckling child cannot be excluded.
A decision must be made whether to discontinue breastfeeding or to discontinue/abstain from glyceryl trinitrate therapy taking into account the benefit of breastfeeding for the child and the benefit of therapy for the woman.
Fertility: Reproduction toxicity studies performed in rats and rabbits using various routes of administration did not reveal any effect on mating, fertility, and general reproductive parameters. There is no data available on the effect of glyceryl trinitrate on fertility in humans.